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The cardiac malformations in the paroxetine-exposed infants were primarily ventricular septal defects vsds and atrial septal defects asds .
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paroxetine produces no clinically significant changes in blood pressure, heart rate and ecg after administration to healthy subjects.
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in a controlled study of healthy volunteers, after paroxetine tablets were titrated to 60 mg daily, co-administration of a single dose of 2 mg pimozide was associated with mean increases in pimozide auc of 151 and c max of 62 , compared to pimozide administered alone.
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if acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, paroxetine tablets should be stopped promptly, and linezolid or methylene blue can be administered.
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