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Direct neonatal exposure of tamoxifen to mice and rats not via breast milk produced reproductive tract lesions in female rodents similar to those seen in humans after intrauterine exposure to diethylstilbestrol and functional defects of the reproductive tract in male rodents.

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er women who took tamoxifen for 1-2 years had nearly as great a reduction in recurrence in years 0-4 as those who took it for it for five years.

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