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If metformin-associated lactic acidosis is suspected, general supportive measures should be instituted promptly in a hospital setting, along with immediate discontinuation of glucovance.
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92 the mechanism by which biguanides increase the activity of ampk remains uncertain; however, metformin increases the concentration of cytosolic adenosine monophosphate amp as opposed to a change in total amp or total amp adenosine triphosphate .
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