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Relative to placebo, naltrexone decreased reward activation to chocolate in the dorsal anterior cingulate cortex and caudate, and increased aversive-related activation to unpleasant strawberry in the amygdala and anterior insula.
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an in vitro cyp inhibition study demonstrated that naltrexone is not an inhibitor of major cyp enzymes cyp 1a2, 2a6, 2b6, 2c8, 2c9, 2c19, 2d6, 2e1, 3a4 .
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these data indicate that long-acting naltrexone can be of benefit in the treatment of alcohol dependence.
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