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Reduced uptake of methotrexate into cells.

Therefore, methotrexate interferes with dna synthesis, repair, and cellular replication.

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Side effects associated with methotrexate may vary from person to person.

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Methotrexate is also sometimes used in combination with other medications to treat bladder cancer.

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methotrexate polyglutamates inhibit the enzyme aminoimidazolecarboxamidoadenosineribonucleotide aicar transformylase more potently than the other enzymes involved in purine biosynthesis.

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