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It should be kept in mind that unlike muscarinic effects, the skeletal muscle effects and consequent respiratory paralysis nicotinic effects which can occur following mestinon overdosage are not alleviated by atropine.

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the effect of mestinon-sr is presumed to result from its reversible inhibition of a critical number of acetylcholinesterase active sites in the peripheral nervous system, protecting them from irreversible inhibition by soman.


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