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Diarrhea is a somewhat troubling symptom and when very frequent and watery, requires extra vigilance since amoxicillin along with clindamycin, ampicillin, and the cephalosporins tend to be the worst offenders in an uncommon but dangerous antibiotic induced pseudomembranous colitis pmc .
Clindamycin is metabolized predominantly by cyp3a4, and to a lesser extent by cyp3a5, to the major metabolite clindamycin sulfoxide and minor metabolite n desmethylclindamycin.
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The use of clindamycin phosphate may result in overgrowth of nonsusceptible organisms- particularly yeasts.
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